Enhancing the Detectable Chemical Space in an Effluent-Dominated Stream: Non-Target Analysis Reveals Potential Rapid <i>In Situ</i> Product Formation.

ABSTRACT: Effluent-dominated streams are increasingly common in temperate regions and have potential for adverse ecological and human health effects. Nontarget analysis (NTA) using high resolution mass spectrometry (HRMS) is an emerging approach to examine complex chemical mixtures in the environment. Here, we leveraged archived samples previously analyzed for 154 target contaminants in a well-studied temperate region effluent-dominated stream and compared target results with suspected compounds from NTA. NTA enhanced the detectable chemical space by 20 times compared to target analysis alone. Target analysis was biased toward larger mass contaminants compared to the compounds detected with NTA, indicating that target analysis was not fully representative of the compound distribution for the effluen

SUBMITTER: Mianecki AL 

PROVIDER: S-EPMC12351525 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature