Vonoprazan and amoxicillin dual therapy versus bismuth-based therapy for <i>Helicobacter pylori</i> eradication: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Introduction

Helicobacter pylori infection can cause peptic ulcer disease, chronic gastritis, primary gastric lymphoma, and gastric cancer. Treatment with bismuth-based quadruple therapy is typically the first line of treatment but can be challenging due to increased pill burden and adverse effects, leading to nonadherence to therapy. Recent studies have shown that vonoprazan can be used in combination with amoxicillin as a potential treatment option. We conducted a systematic review and meta-analysis to assess the efficacy and tolerability of vonoprazan-based dual therapy as compared to bismuth-based therapy (BBT).

Methodology

We conducted a comprehensive search of multiple electronic databases including PubMed, Embase, and Cochrane Library to identify randomized con

SUBMITTER: Abosheaishaa H 

PROVIDER: S-EPMC12351748 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature