Insulin resistance, metabolic dysfunction-associated steatotic liver disease, and advanced liver fibrosis in lean US adults: a population-based study.

ABSTRACT:

Background

While insulin resistance (IR) and metabolic dysfunction-associated steatotic liver disease (MASLD) are well established in obese individuals, their connection in lean populations remains underexplored.

Methods

This cross-sectional study investigated the relations of IR with MASLD and advanced liver fibrosis based on data from the 2017-2020 US National Health and Nutrition Examination Surveys. The subjects were lean adults (non-Asian body mass index [BMI] < 25 kg/m², Asian BMI <23 kg/m²) with transient elastography data, free from viral hepatitis, human immunodeficiency virus, excessive alcohol use, and diabetes. Multivariable generalized linear and logistic regression models were used to relate IR measures to hepatic fat content and visceral

SUBMITTER: Njei B 

PROVIDER: S-EPMC12351751 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature