Habitual sweet and bitter beverage consumption in relation to the risk of frailty and sarcopenia-related traits: a Mendelian randomization study.

ABSTRACT: Previous studies have associated different beverage types with frailty and sarcopenia, it remains uncertain whether these associations are causal. This Mendelian randomization study aimed to investigate the causal effects of various beverage consumption on frailty and sarcopenia-related traits. Independent genetic variants strongly (P < 5E-8) associated with sweet and bitter beverages and their subtypes were used as instrumental variables. Summary-level data from recent genome-wide association studies on frailty index (FI), appendicular lean mass (ALM), and low hand grip strength (LHGS) were utilized, with false discovery rate (FDR) adjustment for multiple comparisons. Genetically predicted consumption of bitter non-alcoholic beverages (BNaBs) was associated with increased FI (β = 0.16, 95

SUBMITTER: Guo X 

PROVIDER: S-EPMC12351878 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature