Precision-Engineered Co-N<sub>4-<i>x</i></sub> -C <i><sub>x</sub></i> Single Atoms Enhance Potential-Resolved Ru(bpy)<sub>3</sub> <sup>2+</sup> Electrochemiluminescence via Reactive Oxygen Species.
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ABSTRACT: Electrochemiluminescence (ECL) immunoassays based on tris(bipyridine)ruthenium [Ru(bpy)3 2+] is the luminophore representing the most advanced and widely adopted approach in the field of in vitro diagnostics (IVD). However, the scarcity of potential-resolved ECL promoters for Ru(bpy)3 2+ markedly limits its application in clinical diagnostics. Here, we report the first application of cobalt single-atom catalysts (SACs) designed via density functional theory (DFT) calculations to boost the multi-signal ECL of Ru(bpy)3 2+. Mechanism investigations unveil that "ROS accumulation" induced by CoC4 and "ROS surge" driven by CoN4 are the key factors governing the cathodic and anodic ECL. As a proof of concept,
SUBMITTER: Kang Z
PROVIDER: S-EPMC12351920 | biostudies-literature | 2025
REPOSITORIES: biostudies-literature
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