Examining the timing of trauma, PTSD onset, and DNA methylation: A multicohort investigation of candidate CpG sites.

ABSTRACT: Epigenome-wide association studies (EWAS) have identified cytosine-phosphate-guanine sites (CpGs) associated with trauma and PTSD. However, prior studies have largely focused on cross-sectional associations, and it remains unclear whether epigenetic profiles associated with traumatic stress might predispose individuals to develop PTSD or might change in response to PTSD. In this study, we characterized associations between traumatic stress and three CpGs identified in previous EWAS of PTSD (cg05575921 and cg26703534 in AHRR, and cg19534438 in G0S2) using two cohorts-the Dunedin Multidisciplinary Health and Development Study (n = 846) and the Post-Deployment Mental Health Study (PDMH; n = 2309). We first replicated cross-sectional associations, and then investigated the time course linking

SUBMITTER: Bourassa KJ 

PROVIDER: S-EPMC12352127 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature