Palladium-catalysed methylene C(<i>sp</i> ³)-H lactamization and cycloamination enabled by chlorinated pyridine-pyridone ligands.

ABSTRACT: Recent developments of bifunctional ligands have rapidly advanced palladium-catalyzed C(sp ³)-H activation reactions directed by native carboxylic acids. However, using this approach in inter or intramolecular C(sp ³)-H amination reactions is often hampered by N-coordination overriding the directing effect of the native carboxyl group. Here, we report the design and development of chlorinated pyridine-pyridone ligands, which can overcome N-coordination and enable exclusive carboxylic-acid directed lactamization and cycloamination of N-protected ω-amino acids. The compartmentalization of directed C(sp ³)-H activation and C(sp ³)-N bond formation in this reaction is distinct from existing C(sp

SUBMITTER: Sam Chan HS 

PROVIDER: S-EPMC12352273 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature