Right stellate ganglion stimulation modulates arrhythmogenesis in acute left lateral ventricular ischaemia.

ABSTRACT:

Aims

Acute myocardial ischaemia causes fatal arrhythmias as result of a flow of 'injury current'. Left stellate ganglion stimulation (LSGS) modulates the injury current and is arrhythmogenic during left anterior ventricular wall ischaemia. The role of right stellate ganglion stimulation (RSGS) in arrhythmogenesis is unclear. We hypothesized that RSGS is proarrhythmic during left lateral ventricular wall ischaemia.

Methods and results

In 11 anaesthetized female pigs, ventricular repolarization was measured in unipolar epicardial electrograms from the left lateral ventricular wall. Seven subsequent episodes of acute ischaemia (5 min) were produced by occlusion of the circumflex coronary artery (CX), separated by 20 min of reperfusion. The second occlusion served as a control.

SUBMITTER: Hadaya J 

PROVIDER: S-EPMC12352303 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature