Urate-lowering effects of polyphenolic compounds in animal models: systematic review and meta-analysis.

ABSTRACT:

Background

Recent research underscores the critical role of uric acid (UA) in the pathogenesis and progression of various diseases. However, the effects of polyphenolic compounds on uric acid levels remain poorly defined.

Objective

This review aims to assess the impact of five specific polyphenolic compounds on uric acid levels in animal models.

Methodology

We performed an exhaustive literature search through October 30, 2024, utilizing databases including Wanfang, VIP, Cochrane Library, CNKI, Embase, and PubMed. The methodological quality of the included animal studies was evaluated using the SYRCLE (Systematic Review Centre for Laboratory animal Experimentation) risk of bias tool. Data analysis was conducted using R software, with meta-analyses performed via

SUBMITTER: Chen J 

PROVIDER: S-EPMC12352422 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature