Neural mechanisms of reward processing in preadolescent irritability: Insights from the ABCD study.

ABSTRACT: Elevated youth irritability is characterized by increased proneness to frustration relative to peers when rewards are blocked, and is a transdiagnostic symptom that predicts multiple forms of psychopathology and poorer socioeconomic outcomes in adulthood. Although mechanistic models propose that irritability is the result of aberrant reward-related brain function, youth irritability as it relates to multiple components of reward processes, including reward anticipation, gain, and loss, has yet to be examined in large, population-based samples. Data from the Adolescent Brain and Cognitive Development (ABCD) baseline sample (N = 5923) was used to examine associations between youth irritability (measured by parent-report) and reward-related brain activation and connectivity in a large, preado

SUBMITTER: Parker AJ 

PROVIDER: S-EPMC12352463 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature