Activity-dependent development of synaptic circuits mediates direction selectivity in an axis-specific manner.

ABSTRACT: The optokinetic reflex (OKR), which stabilizes images on the retina as a mouse navigates its environment, originates in direction-selective ganglion cells (DSGCs). A mouse model that lacks cholinergic retinal waves, the β2-nAChR-KO mouse, does not develop horizontal direction selectivity but preserves vertical direction selectivity. Here, we demonstrate that the absence of horizontal direction selectivity in β2-nAChR-KO mice results in a loss of the OKR along the horizontal axis, consistent with previous findings on optomotor response. In addition, we observe diminished asymmetric inhibition onto horizontal-preferring DSGCs. In contrast, OKR along the vertical axis and asymmetric inhibition onto vertical-preferring DSGCs is maintained. Dual whole-cell voltage-clamp recordings show that thi

SUBMITTER: Bistrong K 

PROVIDER: S-EPMC12352496 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature