Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair.

ABSTRACT: Circulating group 2 innate lymphoid cells (ILC2s) comprise a third of all lung ILC2s shortly after helminth infection, providing an early source of type-2 cytokines. However, the origin of circulating ILC2s and their relationship with ILC progenitors and tissue-resident ILC2s remain unresolved. Single-cell RNA-sequencing and trajectory analysis of ILC2 and ILC2 progenitors in the lung, bone marrow (BM), and intestine draining lymph nodes (LNs) revealed that circulating ILC2s in the lung mirror a population of ILC2s in the mesenteric LNs. Conversely, lung-resident ILC2s closely resembled BM ILC progenitors. These BM progenitors gave rise to lung-resident ILC2s but not circulating ILC2s after adoptive transfer. Definitive proof of an intestinal origin for circulating ILC2s in the lung was ac

SUBMITTER: Can UI 

PROVIDER: S-EPMC12352581 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature