IgG promotes TNF-α induced osteoclastogenesis by upregulating the expression of TNFR1 and the NF-κB signalling pathway.

ABSTRACT:

Objectives

Tumor necrosis factor-α (TNF-α) plays a pivotal role in bone damage associated with inflammatory arthritis such as rheumatoid arthritis (RA). Both systemic lupus erythematosus (SLE) and rheumatoid arthritis exhibit clinical manifestations of inflammatory arthritis, yet the joint bone damage in RA is more severe than that in SLE. The reasons for this differential manifestation remain unclear. This study aimed to determine the role of IgG antibodies in TNF-α-induced osteoclastogenesis.

Methods

We conducted cellular experiments to ascertain whether IgG affects TNF-α-induced osteoclastogenesis and validate the role of IgG in TNF-α-induced cartilage destruction in mouse models of arthritis through animal studies.

Results

We found that IgG promoted TNF-α-induced

SUBMITTER: Yin H 

PROVIDER: S-EPMC12352583 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature