SARS-CoV-2 infection and new-onset type 1 diabetes in the post-acute period among children and young people in England.

ABSTRACT:

Aims

To examine if SARS-CoV-2 infection is associated with new-onset type 1 diabetes in the post-acute period in children and young people (CYP).

Methods

In this population cohort, we used data on all hospital activity in England to estimate type 1 diabetes incidence among CYP aged 0-17 exposed to SARS-CoV-2 between May 2020 and August 2022, from day 28 after a positive test for the following 6 months. We compared this with unexposed CYP who were hospitalized for elective procedures or following trauma during the pandemic, and in the 2 years prior to the pandemic (historic cohorts). We excluded CYP with prior chronic illnesses. We undertook Cox regression analyses adjusted for age, sex, ethnicity, deprivation and season of index date, and stratified by periods when different

SUBMITTER: Ward JL 

PROVIDER: S-EPMC12352718 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature