Enhanced Near-Infrared-Excitable Organic Afterglow Nanoparticles for Deep-Tissue Multimodal Imaging via Singlet Oxygen-Mediated Energy Transfer.

ABSTRACT: Afterglow imaging offers exceptional signal-to-background ratios (SBRs) by circumventing real-time excitation and autofluorescence, yet conventional systems rely on visible-light excitation, limiting tissue penetration and signal intensity. Here, we report near-infrared-excitable organic afterglow nanoparticles (NOANPs) that leverage singlet oxygen (¹O₂)-mediated energy transfer to achieve prolonged, high-intensity emission with minimal photobleaching. The nanoparticles integrate a near-infrared-photoactive sensitizer (NAM-0), which generates abundant ¹O₂ under 808-nm laser excitation, and a triplenet-anthracene derivative (TD) as the afterglow substrate, which converts ¹O₂ into sustained luminescence. Co-encapsulation via o

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12352855 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature