A noncanonical parasubthalamic nucleus-to-extended amygdala circuit converts chronic social stress into anxiety.

ABSTRACT: Anxiety disorders pose a substantial threat to global mental health, with chronic stress identified as a major etiologic factor. Over the past few decades, extensive studies have revealed that chronic stress induces anxiety states through a distributed neuronal network of interconnected brain structures. However, the precise circuit mechanisms underlying the transition from chronic stress to anxiety remain incompletely understood. Employing the chronic social defeat stress (CSDS) paradigm in mice, we uncovered a critical role of the parasubthalamic nucleus (PSTh) in both the induction and expression of anxiety-like behavior. The anxiogenic effect was mediated by an excitatory trisynaptic circuitry involving the lateral parabrachial nucleus (LPB), PSTh, and bed nucleus of the stria terminal

SUBMITTER: Liu N 

PROVIDER: S-EPMC12352892 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature