Lung function trajectories in children with pulmonary TB and non-TB lower respiratory tract infections.

ABSTRACT:

Background

This longitudinal study compared lung function in children with pulmonary TB (PTB), children with non-TB lower respiratory tract infections (LRTIs) and healthy controls.

Methods

Children aged 4-13 years presenting with presumed PTB and their healthy siblings who could perform spirometry were included. Children were classified as having TB, non-TB LRTIs after careful evaluation and during follow-up. Spirometry measurements were completed at baseline and at subsequent study visits during 52 weeks of follow-up. Measurements included forced expiratory volume in 1 second (FEV₁), forced vital capacity (FVC), and FEV₁/FVC using 2022 race-neutral Global Lung Initiative reference ranges.

Results

Of 143 children, 46 had TB, 64 had non-TB LRTIs,

SUBMITTER: Courtney IJ 

PROVIDER: S-EPMC12352954 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature