ER + HER2- early-stage breast cancer: association of HER2 expression, tumor characteristics, and outcomes.

ABSTRACT:

Purpose

To evaluate the association between the HER2 score as provided by the Oncotype DX Recurrence Score (RS) assay, tumor characteristics, and outcomes in early-stage, ER + HER2-negative breast cancer (BC).

Methods

All women insured by the Clalit Health Services, with early-stage, ER + HER2-negative BC who underwent RS testing between 2008 and 2011 were included. Patient/tumor characteristics and Kaplan-Meier estimates for distant recurrence-free survival (DRFS) and overall survival (OS) were compared by HER2 category, based on the HER2 score provided by the RS assay: lower HER2 score group representing the lower third of the HER2 score range (≤ 8.5); higher HER2 score group representing the upper 2 thirds of the HER2 score range (8.6-10.7).

Results

1535 patients w

SUBMITTER: Goldvaser H 

PROVIDER: S-EPMC12353014 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature