Skeletal muscle and subcutaneous fat quantity as prognostic indicators in cardiac amyloidosis.

ABSTRACT:

Aims

Disease-related changes in body composition are associated with worse outcomes in chronic heart failure. In cardiac amyloidosis (CA), the prognostic value of direct body composition measures is understudied.

Methods and results

We identified 160 consecutive patients with CA (transthyretin [ATTR] or light chain [AL]) diagnosed between 2001 and 2021 who had chest computed tomography within 1 year before diagnosis. Skeletal muscle index (SMI), intermuscular adipose tissue percentage (IMAT%), and subcutaneous adipose tissue index (SATI) were quantified at the twelfth vertebral level and analysed continuously, in sex-stratified tertiles, and with derived outcome-based cutoffs. In a comprehensive model including IMAT% and SATI, only SMI independently predicted 10-year mortali

SUBMITTER: Longinow J 

PROVIDER: S-EPMC12353106 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature