Differential Insular Cortex Activation During Reward Anticipation in Major Depressive Disorder With and Without Anxiety.

ABSTRACT:

Background

Anticipation involves preparatory resource allocation to optimize upcoming responses, linked to insular cortex function. Although individuals with major depressive disorder (MDD) show impairments in anticipatory processing and blunted insula activation, it is unclear whether this pattern holds across MDD with comorbid anxiety disorders (MDD+ANX) and MDD without comorbid anxiety disorders. The monetary incentive delay (MID) task, combined with magnetic resonance imaging (MRI)-guided electroencephalography (EEG) source localization, offers a robust approach to study anticipatory mechanisms in MDD subtypes.

Methods

Participants with MDD (n = 53) or MDD+ANX (n = 108) and healthy control participants (CTLs; n = 38) completed the MID task during simultaneous EEG-MRI rec

SUBMITTER: Ren X 

PROVIDER: S-EPMC12353279 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature