Plasma inflammatory cytokines are associated with cognitive impairment after acute minor ischemic stroke and transient ischemic attack.

ABSTRACT:

Background

Inflammation plays a complex role in post-stroke cognitive impairment (PSCI). The purpose of our study was to explore the possible relationship between peripheral blood inflammatory biomarkers and PSCI.

Methods

This prospective observational cohort study included patients with mild ischemic stroke and transient ischemic attack (TIA) who were hospitalized at the First Hospital of Jilin University between April 2019 and March 2022. Fasting plasma, collected on the second day after admission, was used to detect 10 inflammatory cytokines by ELISA and multifactorial assay. The Montreal Cognitive Assessment scale score < 22 was used as the diagnostic criterion for PSCI. We explored the associations between baseline plasma cytokines and PSCI at 0-30 months of follow-up u

SUBMITTER: Zhao P 

PROVIDER: S-EPMC12353376 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature