Characterizing Recent PDMS Changes in Electrokinetic-Based Microfluidic Devices' Performance and Manufacturing for Cell Sorting Applications.

ABSTRACT: Understanding cells from complex biological samples is vital to understanding cellular biology and medical applications. One evolving tool for cell sorting is the use of microfluidic devices to achieve higher precision and remove the need for labeling cell subpopulations. However, few microfluidic devices have been translated commercially beyond academic research often due to challenges in larger scale fabrication. Here, we initially investigated a compelling label-free microfluidic device with complex geometries to perform contactless dielectrophoresis (cDEP) for applications in enriching cell subpopulations in oncology, neurology, stem cells, and sample preparation. We began scaling the manufacturing of cDEP devices using Dow Sylgard 184, more commonly referred to as PDMS (polydimethylsi

SUBMITTER: Hyler AR 

PROVIDER: S-EPMC12353399 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature