Apolipoprotein E (APOE) Genotype and Cognitive Outcomes of Snoring in a Large Cohort of Adolescents.

ABSTRACT:

Objective

The objective of this study is to investigate whether apolipoprotein E (APOE) ε4 genotype is associated with lower cognitive performance in children with habitual snoring and to determine if APOE could stratify children with snoring by their risk for adverse cognitive outcomes.

Methods

We performed a secondary analysis of the Adolescent Brain Cognitive Development (ABCD) dataset, which included approximately 12,000 children aged 9-10 years recruited between June 2016 and October 2018, with follow-up data from years 1 and 3. Cognitive performance was assessed using the National Institutes of Health Toolbox (NIH-TB) Cognitive Battery. Snoring frequency was evaluated using the Sleep Disorders Scale for Children and categorized as none, non-habitual (< 3 nights/week),

SUBMITTER: Isaiah A 

PROVIDER: S-EPMC12353561 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature