Peripheral arterial disease associated with elevated lipoprotein(a): a review of the evidence and treatment approaches.

ABSTRACT:

Purpose of review

Peripheral arterial disease (PAD) is an atherosclerotic and thrombotic disease associated with substantial morbidity and mortality. Although risk factors for PAD are mostly modifiable, prognosis remains poor, and patients are at a high risk of cardiovascular events. This review aims to summarize current evidence surrounding the role of lipoprotein(a) (Lp[a]) in PAD and examines the available data on lipoprotein apheresis as an effective management approach for patients with PAD with elevated Lp(a).

Recent findings

Evidence strongly indicates that elevated Lp(a) is a causal and independent risk factor for PAD and is associated with PAD severity and increased risk of adverse outcomes, including major adverse cardiovascular events and major adverse limb events

SUBMITTER: Bhatia HS 

PROVIDER: S-EPMC12353575 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature