Association of carotid atherosclerosis with brain tissue integrity and metabolic parameters in type 2 diabetes patients.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is known to adversely impact brain health, leading to cognitive decline and brain tissue volume reduction. This study aimed to assess the damage to gray-white matter junction tissue volume (gwJTV) in T2DM patients with and without carotid artery plaques, and its association with various metabolic parameters.

Methods

We conducted a cross-sectional study involving 69 T2DM patients, employing three-dimensional T1-weighted MRI scans to measure brain tissue volumes, particularly gwJTV, and analyzing blood samples for metabolic parameters. Voxel-based (VBA) and region-of-interest (ROI) analyses of gwJTV were performed to evaluate the group difference with and without carotid artery plaques and to determine correlations to metabolic biomar

SUBMITTER: Lim SH 

PROVIDER: S-EPMC12353737 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature