The ubiquitin-like modifier FAT10 is not essential for MHC-I antigen presentation.

ABSTRACT:

Introduction

The presentation of pathogen-derived antigens on major histocompatibility complex (MHC) class I is crucial for the antiviral immune response. Degradation of intracellular pathogen-derived proteins by the 26S proteasome generates peptides that can be loaded on MHC-I molecules and presented to cytotoxic T cells. The cytokine-inducible ubiquitin-like modifier (ULM) HLA-F adjacent transcript 10 (FAT10) is encoded in the MHC locus and targets its substrates for proteasomal degradation. Therefore, it acts as an alternative signal for protein degradation, indicating a role in generating the peptide pool for MHC-I presentation. In this study, we aimed to elucidate the role of FAT10 in MHC class I presentation.

Methods

Using different human and mouse cell lines deficient

SUBMITTER: Pach N 

PROVIDER: S-EPMC12353742 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature