Association between serum anion gap trajectory and mortality in hospitalized patients with sepsis: an analysis of the MIMIC-IV database.

ABSTRACT:

Background

Sepsis remains a leading cause of mortality in intensive care units (ICUs), with high morbidity and healthcare costs worldwide. The serum anion gap (AG), a marker of metabolic acidosis, has been associated with adverse outcomes in various critical illnesses. However, the prognostic value of longitudinal AG trajectories in sepsis remains underexplored. This study explored the link between dynamic AG trajectories and all-cause mortality in critically ill septic patients.

Methods

A retrospective cohort study utilized data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Adult patients meeting Sepsis-3 criteria for sepsis were included. Group-based trajectory modeling was used to identify AG trajectories during the initial five days of ICU

SUBMITTER: Jing L 

PROVIDER: S-EPMC12353743 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature