Dissecting Schizophrenia Biology Using Pleiotropy With Cognitive Genomics.

ABSTRACT:

Background

Given the increasingly large number of loci discovered by psychiatric genome-wide association studies (GWASs), specification of the key biological pathways that underlie these loci has become a priority for the field. We have previously leveraged the pleiotropic genetic relationships between schizophrenia (SCZ) and 2 cognitive phenotypes (educational attainment and cognitive task performance) to differentiate 2 subsets of illness-relevant single nucleotide polymorphisms (SNPs): 1) those with concordant alleles, which are associated with reduced cognitive performance and educational attainment and increased SCZ risk, and 2) those with discordant alleles, which are linked to reduced educational and/or cognitive levels but lower SCZ susceptibility.

Methods

In the cur

SUBMITTER: Bhattacharyya U 

PROVIDER: S-EPMC12353775 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature