Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging.

ABSTRACT: The brain barrier system, including the choroid plexus, meninges and brain vasculature, regulates substrate transport and maintains differential protein concentrations between blood and cerebrospinal fluid (CSF). Aging and neurodegeneration disrupt brain barrier function, but proteomic studies of the effects on blood-CSF protein balance are limited. Here we used SomaScan proteomics to characterize paired CSF and plasma samples from 2,171 healthy or cognitively impaired older individuals from multiple cohorts, including the Global Neurodegeneration Proteomics Consortium. We identified proteins with correlated CSF and plasma levels that are produced primarily outside the brain and are enriched for structural domains that may enable their transport across brain barriers. CSF to plasma ratios

SUBMITTER: Farinas A 

PROVIDER: S-EPMC12353824 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature