Comparison of open and endovascular therapy for infrainguinal acute limb ischemia in the era of percutaneous thrombectomy.

ABSTRACT:

Objective

Endovascular treatment of acute limb ischemia, primarily consisting of catheter-directed thrombolysis (CDT), has been shown to reduce mortality without affecting limb salvage. Percutaneous thrombectomy (PT) devices have expanded endovascular approaches while decreasing thrombolytic use. Although many advocate for an endovascular-first approach, it is unclear which patients would benefit most from each strategy.

Methods

We included adults (18+) who underwent revascularization for infrainguinal acute limb ischemia (January 2016 to December 2023) at a multi-hospital health care system. We compared amputation and mortality after endovascular vs open approaches using logistic regression, Kaplan-Meier curves, and Cox regression.

Results

We included 315 patients: 1

SUBMITTER: Jarosinski MC 

PROVIDER: S-EPMC12353855 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature