EEG signal dimension is an index of seizure propensity and antiseizure medication effects in a mouse model of acquired epilepsy.

ABSTRACT:

Objective

Variability in the frequency, timing, and pattern of seizures may influence the assessment of the effect of antiseizure medications (ASMs) when measuring seizure frequency, especially in patients with infrequent seizures. A low seizure rate is an exclusion criterion for enrollment of patients with epilepsy in clinical trials and requires prolonged periods of seizure monitoring, thus delaying appropriate treatment interventions. We investigated whether an electroencephalogram (EEG)-based complexity measure of seizure susceptibility of epileptic mice provides a reliable alternative to seizure frequency for evaluating the efficacy of ASMs.

Methods

We used a mouse model of acquired epilepsy characterized by variability in seizure frequency over time and among mice, as

SUBMITTER: Rizzi M 

PROVIDER: S-EPMC12353893 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature