Cortical Effects of Dopamine Replacement Account for Clinical Response Variability in Parkinson's Disease.

ABSTRACT:

Background

Individual variability in clinical response to dopamine replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources of such interindividual differences is necessary to personalize DRT prescribing, inform future clinical interventions, and motivate translational research.

Objective

One potential source of this variability is an unintended secondary activation of extra-nigrostriatal dopamine systems by DRT, particularly in the neocortex. Our goal was to determine the clinical effects of cortical dopamine system activation by DRT in patients with PD.

Methods

We used pharmaco-magnetoencephalography data collected from patients with PD (N_PD = 17,

SUBMITTER: Wiesman AI 

PROVIDER: S-EPMC12353942 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature