Funisitis increases the risk of death or cerebral palsy in extremely preterm infants.

ABSTRACT:

Background

The relationship between histological chorioamnionitis (inflammation of fetal membranes) and funisitis (inflammation of umbilical cord), both commonly associated with preterm birth, with subsequent development of cerebral palsy remains controversial.

Objective

To determine if extremely preterm infants (<27 weeks) exposed to histological chorioamnionitis or funisitis are at a higher risk of death or cerebral palsy compared to those without these exposures.

Study design

Multicenter cohort study of prospectively collected data of preterm infants in the National Institute of Child Health and Development Neonatal Research Network. Infants born 2012 to 2019 who were 22 to 26^6/7 weeks of gestation, received active treatment, and had placental pathology

SUBMITTER: Jain VG 

PROVIDER: S-EPMC12353965 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature