Techno-economic analysis of membrane-based continuous capture chromatography platforms for large-scale antibody production.

ABSTRACT: Continuous manufacturing platforms and membrane chromatography are process technologies with the potential to reduce production costs and minimize process variability in monoclonal antibody production. This study presents a simulation and optimization framework to perform techno-economic analyses of these strategies. Multi-objective optimization was used to compare batch and continuous multicolumn operating modes and membrane and resin process alternatives, revealing performance differences in productivity and cost of goods attributed to variations in dynamic binding capacity, media geometry, and process residence time. From the set of optimal process configurations, we selected one membrane and one resin platform alternative yielding the highest net present values to undergo sensitivity a

SUBMITTER: Romero JJ 

PROVIDER: S-EPMC12353975 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature