IFNγ Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy.

ABSTRACT:

Background

Eosinophilic Esophagitis (EoE) is a chronic food allergy that causes esophageal inflammation and fibrosis and manifests with symptoms of reflux, chest pain, swallowing difficulty, and food impactions. Though the prevalence of EoE is increasing by ~15% each year, our understanding of EoE immunopathology is limited. A noted feature of EoE is the presence of food-specific IgG4 antibodies in the circulation and esophageal tissue. Production of IgG4 is confined to IL-10⁺ B cells (Bregs) in other allergic diseases, suggesting Bregs may be present in EoE.

Methods

We examined circulating Bregs in patients with EoE milk allergy. In parallel, we performed mechanistic investigations of the role of Bregs in a murine model of food-antigen-dependent EoE. Flow cytomet

SUBMITTER: Clement RL 

PROVIDER: S-EPMC12354031 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature