Identifying antimalarials that disrupt malaria parasite transmission when fed to the mosquito.

ABSTRACT: A decade-long decline in malaria cases has plateaued, primarily due to parasite drug resistance and mosquito resistance to insecticides used in bed nets and indoor residual spraying. Here, we explore the innovative control strategy targeting Plasmodium with antimalarials during the mosquito stages. This strategy has the potential to reduce the risk of resistance emerging because a relatively small population of parasites within the mosquito is subject to selection. After validating mosquito feeding strategies, we screened a range of parasiticidal compounds by feeding them to mosquitoes already infected with mouse malaria (P. berghei). Three antimalarials showed activity against P. berghei in mosquitoes, apparently targeting specific stages of P. berghei development during transmission. Bor

SUBMITTER: Farrell SN 

PROVIDER: S-EPMC12354145 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature