Cost-effectiveness of Lynch Syndrome Screening in Colorectal Cancer: Universal Germline vs Sequential Screening.

ABSTRACT:

Background & aims

Testing all colorectal cancers (CRCs) for mismatch repair status to evaluate for Lynch syndrome (LS) has been recommended for years. Owing to attrition in the multistep diagnostic testing pathway, most qualifying patients still do not receive genetic testing for LS. This leads to missed diagnoses and preventable cancer incidence. To tackle this, we previously reported a systems approach that resulted in a dramatic increase in the identification of patients with LS. We aim to evaluate the cost-effectiveness of this intervention compared with both real-world pre-intervention experience and with upfront germline testing of all CRC probands.

Methods

We employed data from the Prospective Lynch Syndrome Database, the National Cancer Institute Surveillance, Epidem

SUBMITTER: Ito S 

PROVIDER: S-EPMC12354148 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature