Administration of the Sleep-Promoting Neuromodulator Adenosine Into the Median Preoptic and Septal Region Produced Thermal Hyperalgesia.

ABSTRACT: Abundant clinical and preclinical evidence demonstrates that sleep and pain have bidirectional interactions. Sleep loss enhances pain perception and pain disrupts sleep. However, the exact neurobiological mechanisms through which sleep loss alters pain remain poorly understood. The preoptic area of the hypothalamus is crucial for the regulation of sleep onset and sleep homeostasis, and it innervates downstream regions that regulate arousal states and pain. Adenosine neurotransmission in the preoptic region plays a key role in the sleep homeostatic response following prolonged wakefulness or sleep deprivation. Previous studies showed that pharmacologically blocking adenosine A_2A receptors within the median preoptic nucleus of sleep-deprived rats prevented the increase in pain cau

SUBMITTER: Hambrecht-Wiedbusch VS 

PROVIDER: S-EPMC12354215 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature