Association of Augmentation Index With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Augmentation index (Aix) is a widely used index of pressure wave reflections (PWRs) derived from noninvasive blood pressure waves recordings and pulse wave analysis. Cerebral small vessel disease (cSVD) comprises various pathological processes affecting the brain's microvasculature and is a major cause of vascular cognitive impairment, ischemic, and hemorrhagic stroke. This meta-analysis aimed to assess the association between PWRs, as measured by AIx, and cSVD as identified through neuroimaging biomarkers, and to explore potential differences based on arterial site of AIx measurement.

Methods

Following a predefined protocol adhering to the Meta-Analysis of Observational Studies in Epidemiology guidelines, nine studies comprising a total of 6,774 participants were

SUBMITTER: Karachalias F 

PROVIDER: S-EPMC12354286 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature