Cutaneous Lupus Features Specialized Stromal Niches and Altered Retroelement Expression.

ABSTRACT: Cutaneous lupus is an inflammatory skin disease causing highly morbid inflamed skin and hair loss. To investigate the pathophysiology of cutaneous lupus, we performed single-cell RNA and spatial sequencing of lesional and nonlesional cutaneous lupus skin compared with that of healthy controls. Pathway enrichment analyses of lesional keratinocytes revealed elevated responses to IFN-I, IFN-II, TNF, and apoptotic signaling. Detailed clustering demonstrated unique fibroblasts specific to lupus skin with likely roles in inflammatory cell recruitment and fibrosis. We also evaluated the association of retroelement expression with IFN-I in the skin. We observed increased retroelement expression that correlated with IFN-stimulated genes across multiple cell types. Moreover, we saw elevated expressi

SUBMITTER: Gehlhausen JR 

PROVIDER: S-EPMC12354343 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature