Criteria and non-criteria anti-phospholipid antibodies in the different clinical forms of antiphospholipid syndrome.

ABSTRACT:

Introduction

Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by thrombotic symptoms (venous, arterial, or small vessels) and/or gestational morbidity in patients carrying antiphospholipid antibodies (aPLs). Criteria aPLs include anti-cardiolipin antibodies, anti-beta 2 glycoprotein I (aB2GPI) antibodies of the IgG or IgM isotypes, and lupus anticoagulant (LA). However, there are aPLs that are associated with APS events but are not included in the criteria (extra-criteria). The aim of this study is to evaluate the prevalence and association of criteria and extra-criteria aPLs with APS clinical events.

Methods

A total of 838 patients with clinical manifestations of APS were studied. In total, 715 presented with vascular manifestations, and 130 p

SUBMITTER: Cabrera-Marante O 

PROVIDER: S-EPMC12354381 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature