The impact of considering different numbers of contributors in identification problems involving real casework mixture samples.

ABSTRACT: Increasingly complex genetic samples are analyzed in forensic genetics routine, including mixtures to which more than one individual contributed. The standard problem relies on identification, aiming to quantify the likelihood of the donor of a reference sample being a contributor to the mixture. This is computed through a likelihood ratio (LR) and requires using devoted probabilistic genotyping software that may consider the quantity of the mixture's DNA (quantitative tools), beyond only the presence/absence of specific alleles (qualitative tools). In any case, the mixture's number of contributors (NoC) is a parameter that the user must introduce. Due to its nature, NoC is unknown for most real casework samples and needs to be estimated, which may be challenging due to poor DNA quality an

SUBMITTER: Costa C 

PROVIDER: S-EPMC12354499 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature