Assessment of cardiac biomarker "point-of-care" testing as postmortem diagnostic tool.

ABSTRACT: In cardiac death, some entities, such as arrhythmia or nonocclusive myocardial ischemia, are not associated with clear and certain macroscopic surrogates of cardiac death. Cardiac biomarker point-of-care testing (POCT) seems suitable for further improving postmortem diagnostics in legal medicine casework. Considering the preanalytic phase, the present study aims to define criteria for blood samples suitable for POCT and assess the diagnostic performance of postmortem cardiac biomarker POCT. A fluorescent immunoassay device was used. The biomarkers assessed were myoglobin, brain-type natriuretic peptide (BNP), N-terminal proBNP, creatine kinase muscle-brain type, and cardiac troponin I. Blood was obtained from the intrapericardial inferior vena cava. In a prestudy, criteria for the selectio

SUBMITTER: Federspiel JM 

PROVIDER: S-EPMC12354503 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature