Global trends of early-onset Parkinson's disease from 1990 to 2021, and projections until to 2030: a systematic analysis of the global burden of disease study 2021.

ABSTRACT:

Background

This study aims to evaluate the global, regional, and national trends in prevalence, incidence, mortality, and DALYs for early-onset Parkinson's disease (EOPD) from 1990 to 2021.

Methods

All data from the Global Burden of Diseases (GBD) 2021 were stratified by age, sex, location, and socio-demographic index (SDI). We performed comprehensive analysis to reveal trends for EOPD, utilizing average annual percentage change (AAPC), joinpoint regression analysis, health inequality analysis, frontier analysis, and Bayesian age-period-cohort (BAPC) models.

Results

In 2021, the global case numbers of prevalence, incidence, mortality, and DALYs for EOPD were 483872.47 (95% UI: 328861.91-682509.05), 81046.67 (95% UI: 48161.87-122328.00), 2245.68 (95% UI: 1995.24-2495.6

SUBMITTER: Hu B 

PROVIDER: S-EPMC12354633 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature