Inflammatory markers CRP and WBC as predictors of liver function impairment in multiple injury trauma patients: a repeated measures analysis.

ABSTRACT:

Aims

To investigate the relationship between liver function indices (AST, ALT, GGT) and inflammatory markers (CRP, white blood cell count) in multiple injury patients at different time points post-trauma.

Methods

We retrospectively analyzed 114 patients with multiple injuries admitted to a tertiary trauma center in Zhejiang Province (January 2023-December 2024). AST, ALT, GGT, CRP, white blood cell count, NLR, and LMR were measured at admission, 24 h, and 72 h post-admission. Age, drinking history, BMI, and gender were included as covariates. Statistical analyses employed both crude and adjusted GEE models with gender subgroup analysis.

Results

Elevated CRP levels significantly correlated with increased AST (OR = 2.17, 95% CI: 1.14-4.12, p = 0.019) and ALT (OR 

SUBMITTER: Wang G 

PROVIDER: S-EPMC12354656 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature