A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p.

ABSTRACT: Autism is characterized by impairments in reciprocal communication and social interaction and by repetitive and stereotyped patterns of activities and interests. Evidence for a strong underlying genetic predisposition comes from twin and family studies, although susceptibility genes have not yet been identified. A whole-genome screen for linkage, using 83 sib pairs with autism, has been completed, and 119 markers have been genotyped in 13 candidate regions in a further 69 sib pairs. The addition of new families and markers provides further support for previous reports of linkages on chromosomes 7q and 16p. Two new regions of linkage have also been identified on chromosomes 2q and 17q. The most significant finding was a multipoint maximum LOD score (MLS) of 3.74 at marker D2S2188 on chromos

SUBMITTER: International Molecular Genetic Study of Autism Consortium (IMGSAC) 

PROVIDER: S-EPMC1235486 | biostudies-literature | 2001 Sep

REPOSITORIES: biostudies-literature