PH-responsive magnetic Fe₃O₄ modified chitosan nanoparticles loaded with β-acids to improve colorectal cancer treatment.

ABSTRACT: Oral drug delivery systems designed for antitumor drug administration in colorectal cancer treatment encounter substantial challenges regarding effective delivery, controlled release, and intestinal microbiota homeostasis. In this study, dual-stimulation (pH + magnetic) responsive chitosan nanoparticles (Fe₃O₄/chitosan (CS)/TPP) loaded with hops β-acids were synthesized for colorectal cancer treatment. In vitro experiments revealed that the fabricated nanoparticles demonstrated sizes ranging from 233 to 381 nm, with zeta potential values exceeding 10 mV. Release studies indicated that β-acids release was pH-dependent. Notably, the β-acids-loaded nanoparticles proved antimicrobial activity through membrane protein interactions. Cell proliferation assays confirme

SUBMITTER: Guo S 

PROVIDER: S-EPMC12355082 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature