All-cause and disease-specific mortality in young adults with MASLD: A nationwide cohort study.

ABSTRACT:

Background & aims

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major cause of chronic liver disease globally, particularly among young adults. We aimed to analyze all-cause and disease-specific mortality in young adults with MASLD.

Methods

In this nationwide cohort study, we analyzed data from the Korean National Health Insurance Service, focusing on individuals aged 20 to 39 years who underwent health screenings between 2009 and 2012. The participants were categorized into two groups: those with MASLD and those without steatotic liver disease (SLD). SLD was defined by a fatty liver index ≥30. Mortality risk was analyzed via Cox proportional hazards models.

Results

A total of 5,699,047 participants were included in the study, 25.4% of

SUBMITTER: Park J 

PROVIDER: S-EPMC12355101 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature