Exploring the Antitumor Mechanisms of Bai-Hua-She-She-Cao and Ban-Zhi-Lian against Head and Neck Squamous Cell Carcinoma: A Study on Natural Anticancer Therapeutics.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer with a poor prognosis. This research assessed the in vitro effectiveness and molecular mechanisms of Bai-Hua-She-She-Cao (BHSSC) and Ban-Zhi-Lian (BZL), a traditional Chinese medicinal herb pair against HNSCC. Bioactive compounds and targets of BHSSC-BZL were identified using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) and Swiss Target Prediction databases and cross-referenced with HNSCC-related targets from GeneCards and MalaCards. Network topology analysis identified hub genes, and The Cancer Genome Atlas (TCGA) data determined the protective and risk factors. Molecular docking verified target specificity, and in vitro experiments assessed BHSSC-BZL effects on CAL27 cell proliferation, apoptosis, an

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12355305 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature