Regional lymph node invasion in pediatric non-rhabdomyosarcoma soft tissue sarcoma: an international cohort study from the International Soft Tissue Sarcoma Consortium.

ABSTRACT:

Background

In pediatric non-rhabdomyosarcoma soft tissue sarcoma (NRSTS), the frequency and prognostic impact of regional lymph node involvement (N1) are not clearly defined and may vary according to histological type. We therefore to analyze the rate of N1 at diagnosis, the pattern of nodal relapse, and the prognostic impact of N1 in pediatric patients with NRSTS.

Methods

Data were collected and analyzed through the International Soft Tissue SaRcoma ConsorTium (INSTRuCT). Patients aged 0-21 years with NRSTS prospectively enrolled in European and North American cooperative group trials from October 1, 1990 to October 1, 2018 were included. Descriptive statistics, logistic regressions, and Cox proportional hazards models were used to analyze the data and assess prognostic fac

SUBMITTER: Orbach D 

PROVIDER: S-EPMC12355411 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature